van den Hoven W E, van den Berg T P, Korstanje C
Department of Biological Drug Research, Royal Gist-brocades N.V., Delft, The Netherlands.
Acta Derm Venereol. 1991;71(1):29-31.
The hairless mouse has been used as a model to distinguish between local and systemic atrophogenic effects of topical steroids. Hydrocortisone-17-butyrate, betamethasone-17-valerate, budesonide and clobetasol-17-propionate were applied topically daily for 21 days. Skinfold thickness and dermal DNA synthesis of treated and untreated skin were evaluated as parameters of local and systemic atrophogenicity. Further, body weight gain and thymus weight were assessed as markers of systemic activity. With respect to local effects, skin thickness and dermal DNA synthesis both proved to be good parameters. Of the systemic parameters, thymic involution and body weight gain paralleled quite well the skin thinning on the untreated side. The results confirmed the potency differences of the steroids. Furthermore, they emphasize the usefulness of the hairless mouse to assess the relative safety with respect to local and systemic side effects of chronically applied topical corticosteroids.
无毛小鼠已被用作一种模型，以区分局部类固醇和全身类固醇的萎缩性影响。每天局部应用氢化可的松-17-丁酸酯、倍他米松-17-戊酸酯、布地奈德和丙酸氯倍他索，持续21天。将处理过的皮肤和未处理的皮肤的皮褶厚度及真皮DNA合成作为局部和全身萎缩性的参数进行评估。此外，将体重增加和胸腺重量作为全身活性的标志物进行评估。就局部影响而言，皮肤厚度和真皮DNA合成均被证明是良好的参数。在全身参数方面，胸腺萎缩和体重增加与未处理侧的皮肤变薄情况相当吻合。结果证实了这些类固醇的效力差异。此外，这些结果强调了无毛小鼠在评估长期应用局部皮质类固醇的局部和全身副作用的相对安全性方面的有用性。
