兔实验性动脉粥样硬化中血管胶原和弹性蛋白合成增加。主要血管间合成的差异。

Increased vascular collagen and elastin synthesis in experimental atherosclerosis in the rabbit. Variation in synthesis among major vessels.

作者信息

Fischer G M, Swain M L, Cherian K

出版信息

Atherosclerosis. 1980 Jan;35(1):11-20. doi: 10.1016/0021-9150(80)90023-4.

Abstract

Collagen and elastin synthesis was determined in 5 regions of the vascular system in rabbits on (a) normal diet and (b) atherogenic diet. Increased connective tissue synthesis was found in 3 different sections of the aorta and in the pulmonary artery of rabbits on the atherogenic diet. The inferior vena cava showed no difference between the two groups. Regional variation in connective tissue synthesis was found in both normal and atherosclerotic animals, the vessels associated with the greatest degree of pulsatile distention in vivo having the greatest synthesis and the inferior vena cava, a low pressure, low distention vessel having the lowest synthesis. It is concluded that the atherogenic process includes stimulation of collagen and elastin synthesis. It is suggested that in addition to the effect of pressure on connective tissue synthesis, pulsatile distention may be a factor in synthesis and may be related to lesion formation.

摘要

在兔子的血管系统5个区域测定了胶原蛋白和弹性蛋白的合成情况，这些兔子分别处于（a）正常饮食和（b）致动脉粥样化饮食状态。在喂食致动脉粥样化饮食的兔子的主动脉3个不同节段以及肺动脉中，发现结缔组织合成增加。两组动物的下腔静脉未显示出差异。在正常和动脉粥样硬化动物中均发现了结缔组织合成的区域差异，体内搏动性扩张程度最大的血管合成量最大，而低压、低扩张的下腔静脉合成量最低。得出的结论是，致动脉粥样化过程包括对胶原蛋白和弹性蛋白合成的刺激。有人提出，除了压力对结缔组织合成的影响外，搏动性扩张可能是合成的一个因素，并且可能与病变形成有关。