Langner R O, Modrak J B
Artery. 1981;9(4):253-61.
The effect of hypercholesterolemia on the rate of collagen synthesis in different tissues of the rabbit was investigated. Following 60-70 days of an atherogenic diet cholesterol content and collagen synthesis was estimated in rabbit aorta, liver and lung. All three tissues demonstrated significant increases in cholesterol and cholesterol ester content, but only the aorta and liver had a significant increase in collagen synthetic rate. These data demonstrate 1) that serum hypercholesterolemia does not cause a generalized increase in collagen synthesis in all tissues and 2) that tissue hypercholesterolemia does not always increase tissue collagen synthesis.
研究了高胆固醇血症对兔不同组织中胶原蛋白合成速率的影响。在给予致动脉粥样硬化饮食60 - 70天后，对兔主动脉、肝脏和肺中的胆固醇含量及胶原蛋白合成进行了评估。所有这三种组织的胆固醇和胆固醇酯含量均显著增加，但只有主动脉和肝脏的胶原蛋白合成速率有显著提高。这些数据表明：1）血清高胆固醇血症不会导致所有组织中胶原蛋白合成普遍增加；2）组织高胆固醇血症并不总是增加组织胶原蛋白合成。
