Tolksdorf G, Stein H, Lennert K
Br J Cancer. 1980 Feb;41(2):168-82. doi: 10.1038/bjc.1980.27.
Thirteen lymphomas consisting of one particular cell type were selected from 135 cases of non-Hodgkin's lymphoma. The lymphoma cells were mainly characterized by irregularly shaped nuclei and faintly stained cytoplasm. The growth pattern of the tumour was diffuse. Immunological phenotyping of suspended cells showed that the tumour cells, irrespective of whether they were isolated from lymphoma tissue or from lymphoma tissue or from peripheral blood of leukaemic cases, bore a dense layer of surface immunoglobulin, lacked cytoplasmic immunoglobulin and receptors for mouse erythrocytes, and expressed both complement-receptor subtypes (i.e., receptors for C3b and C3d) in all but one case. The exceptional case was C3b receptor-positive and C3d receptor-negative. The number of IgG-Fc receptor-bearing cells was usually small. There was a consistently small proportion of non-malignant T cells in the tumour tissue. A comparison of the properties of these lymphomas with those of other types of non-Hodgkin's lymphoma and of non-malignant lymphoid cells, shows that the cells of this type of lymphoma (a) differ morphologically and/or immunologically from the cells of all other known types of non-Hodgkin's lymphoma and (b) resemble centrocytes (cleaved follicular-centre cells) of reactive germinal centres. Thus, this type of lymphoma appears to be an entity that is closely related to, or even derived from, centrocytes.
从135例非霍奇金淋巴瘤中选取了13例由单一特定细胞类型构成的淋巴瘤。淋巴瘤细胞的主要特征为细胞核形状不规则，细胞质染色淡。肿瘤的生长方式为弥漫性。悬浮细胞的免疫表型分析显示，肿瘤细胞无论从淋巴瘤组织分离，还是从白血病病例的淋巴瘤组织或外周血分离，均有一层致密的表面免疫球蛋白，缺乏细胞质免疫球蛋白和小鼠红细胞受体，除1例病例外均表达两种补体受体亚型（即C3b和C3d受体）。该例外病例为C3b受体阳性、C3d受体阴性。携带IgG-Fc受体的细胞数量通常较少。肿瘤组织中始终有一小部分非恶性T细胞。将这些淋巴瘤的特性与其他类型非霍奇金淋巴瘤及非恶性淋巴样细胞的特性进行比较，结果表明，这种类型淋巴瘤的细胞：（a）在形态学和/或免疫学上与所有其他已知类型非霍奇金淋巴瘤的细胞不同；（b）类似于反应性生发中心的中心细胞（裂殖滤泡中心细胞）。因此，这种类型的淋巴瘤似乎是一种与中心细胞密切相关甚至源自中心细胞的实体。
