Wickramasekera I
Biofeedback Self Regul. 1980 Mar;5(1):5-18. doi: 10.1007/BF00999060.
A model of the placebo response as a conditioned response (CR) is presented and predictions from this model are listed. Through association with active ingredients (UCS), neutral (CS) places, persons, procedures, and things can come to acquire the ability to reduce pain, anxiety, and depressive responses. One major counterintuitive prediction from the model is that therapists who routinely use active ingredients (UCS) or powerful drugs will get stronger placebo effects than those who routinely use "inert" ingredients (CS) or weak drugs. Developmentally, placebo responding appears to involve two successive conditioning stages, which may involve first the left and later the right hemisphere in right-handed subjects. The relationship between placebo responding and hypnotizability is discussed.
本文提出了一种将安慰剂反应作为条件反应（CR）的模型，并列出了该模型的预测结果。通过与活性成分（无条件刺激，UCS）相关联，中性的地点、人物、程序和事物能够获得减轻疼痛、焦虑和抑郁反应的能力。该模型一个主要的反直觉预测是，经常使用活性成分（UCS）或强效药物的治疗师，会比经常使用“惰性”成分（条件刺激，CS）或弱效药物的治疗师获得更强的安慰剂效应。在发育过程中，安慰剂反应似乎涉及两个连续的条件作用阶段，对于右利手受试者而言，可能首先涉及左半球，随后涉及右半球。本文还讨论了安慰剂反应与催眠易感性之间的关系。
