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[心脏细胞毒性损伤中的能量代谢与心肌收缩活动]

[Energy metabolism and myocardial contractile activity in cardiocytotoxic injury].

作者信息

Moĭbenko A A, Korkach V I, Sagach V F, Frantsuzova S B, Grabovskiĭ L A

出版信息

Biull Eksp Biol Med. 1980 Feb;89(2):151-3.

PMID:7370410
Abstract

It was established in experiments on anesthetized dogs with a closed thorax that injection of anticardiac cytotoxix serum into one of the main branches of the left coronary artery is accompanied by regional disturbances of energy metabolism, manifested by a decrease in ATP, ADP, AMP and glycogen content, and in the contractility of a injured area of the left ventricle. Undamaged myocardium of the left and right ventricles showed a compensatory hyperfunction and an increased level of noradrenaline. The energy metabolism parameters of undamaged cardiac area do not undergo any material changes.

摘要

在对开胸麻醉犬进行的实验中证实,向左冠状动脉的一个主要分支注射抗心脏细胞毒性血清,会伴有能量代谢的局部紊乱,表现为三磷酸腺苷(ATP)、二磷酸腺苷(ADP)、一磷酸腺苷(AMP)和糖原含量降低,以及左心室损伤区域收缩性降低。左、右心室未受损的心肌表现出代偿性功能亢进和去甲肾上腺素水平升高。未受损心脏区域的能量代谢参数未发生任何实质性变化。

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