Golenko O D, Arsenian F G, Miasishcheva N V, Sof'ina Z P
Biull Eksp Biol Med. 1980 Feb;89(2):185-7.
The mechanism of the stimulant effect of methylcobalamine on the growth of mouse adenocarcinoma 755 was studied. More rapid growth of adenocarcinoma 755 under the cobalamine coentzyme effect is consequent on an increased proliferative pool with the stable parameters of the mitotic cycle and minimal death of tumour cells. Apparently, inhibition of DNA synthesis in the greater S-phase cell subpopulation potentiated the antitumour effect of methotrexate combined with methylcobalamine.
研究了甲钴胺对小鼠腺癌755生长的刺激作用机制。在钴胺辅酶作用下，腺癌755生长更快是由于增殖池增加，有丝分裂周期参数稳定，肿瘤细胞死亡最少。显然，在较大的S期细胞亚群中抑制DNA合成增强了甲氨蝶呤与甲钴胺联合的抗肿瘤作用。
