Gerasimova G K, Balinska M, Golenko O D, Miasishcheva N V
Biull Eksp Biol Med. 1981;91(1):57-8.
Methylcobalamin (10 microgram/kg bw, intramuscularly, on the 3d and 5th days after tumor transplantation) or methylcobalamin chlorpalladat -- MeCbl.PdCl3 (250 mg/kg bw in 2% starch suspension per os on the 2d and 6th days) were given to C57BI mice bearing adenocarcinoma Ca--755. On the 8th day after transplantation the methionine synthetase activity and proliferative pool of tumor cells were estimated. It has been disclosed that under the effect of MeCbl the activity of methionine synthetase rises concurrently with an increase in pool of the proliferating cells. Inhibition of tumor growth (by 80--90%) after the treatment with MeCbl.PdCl3 correlated with a decrease in the holoenzyme level in tumor cells.
将甲基钴胺素（10微克/千克体重，于肿瘤移植后第3天和第5天肌肉注射）或氯钯酸甲基钴胺素——MeCbl.PdCl3（250毫克/千克体重，于第2天和第6天以2%淀粉悬液经口给药）给予患有腺癌Ca-755的C57BI小鼠。在移植后第8天，对蛋氨酸合成酶活性和肿瘤细胞增殖库进行评估。结果发现，在MeCbl的作用下，蛋氨酸合成酶活性升高，同时增殖细胞库增加。用MeCbl.PdCl3治疗后肿瘤生长受到抑制（抑制率达80%-90%），这与肿瘤细胞中全酶水平的降低相关。
