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[遗传性视网膜变性中视网膜及其色素上皮的蛋白质]

[Proteins of the retina and its pigmented epithelium in hereditary retinal degeneration].

作者信息

Ostapenko I A, Chusova G G

出版信息

Biull Eksp Biol Med. 1980 Feb;89(2):211-3.

PMID:7370425
Abstract

Water-soluble and membranous proteins of the retina and pigment epithelium were studied by electrophoresis in polyacrylamide gel in Campbell albino rats with inherited retinal dystrophy and in Wistar rats that served as control. It was shown that early changes in abnormal animals were characteristic of retinal proteins. The proteins affected in the first turn proved to be other than cyclic nucleotide phosphodiesterase or opsin. The changes in pigment epithelium were recorded to take place much later.

摘要

通过聚丙烯酰胺凝胶电泳,对患有遗传性视网膜营养不良的坎贝尔白化大鼠以及作为对照的Wistar大鼠的视网膜和色素上皮的水溶性及膜性蛋白质进行了研究。结果表明,异常动物的早期变化以视网膜蛋白质为特征。首先受到影响的蛋白质并非环核苷酸磷酸二酯酶或视蛋白。色素上皮的变化记录显示发生得要晚得多。

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