O'Connor M K, Malone J F, Moriarty M, Cullen M J
Br J Radiol. 1980 Feb;53(626):135-41. doi: 10.1259/0007-1285-53-626-135.
The response of sheep thyroid cells in culture to single doses of X or gamma rays is described. In the absence of cellular proliferation the cells are unusually radioresistant, showing little sign of interphase death at doses up to 9 krad. The follicular morphology characteristic of thyroid cells in vivo is also very radioresistant. Iodide trapping is reduced to 50% of the control value by doses of the order of 2 krad. When proliferation is induced the cells may be assayed for postirradiation survival using a clonogenic endpoint. The survival curves are sigmoid with a Do of 410 rad and a very low extrapolation number.
本文描述了培养的绵羊甲状腺细胞对单次剂量X射线或γ射线的反应。在细胞不增殖的情况下，细胞具有异常的放射抗性，在剂量高达9千拉德时几乎没有间期死亡的迹象。甲状腺细胞在体内的滤泡形态特征也具有很高的放射抗性。剂量达到2千拉德左右时，碘摄取降至对照值的50%。当诱导细胞增殖时，可以使用克隆形成终点来检测照射后细胞的存活率。存活曲线呈S形，Do为410拉德，外推数非常低。
