Cheng D S, Seitz C B, Eyre H J
Cancer. 1980 Apr 1;45(7):1533-7. doi: 10.1002/1097-0142(19800401)45:7<1533::aid-cncr2820450703>3.0.co;2-y.
A retrospective analysis of 59 cases of metastatic breast carcinoma involving the long bones and acetabula was done in an attempt to determine the role of radiation therapy in the management of bone metastases. A total of 97 bone lesions were treated with radiation as the initial therapeutic modality. Seven patients had pathologic fractures when first seen, and 2 had sustained fractures while receiving radiation therapy, and 2, following completion of radiation therapy. All patients had pain relief and improvement in their performance status. A third of patients had radiographic evidence of bone healing. None of the high-risk lesions that may ordinarily be subjected to prophylactic orthopedic stabilization in many medical centers sustained a pathologic fracture after the completion of radiation therapy. We conclude that the use of radiation therapy in initial management of bone metastases in patients with breast cancer is usually effective, and that prophylactic surgical intervention is not warranted in most cases.
对59例发生长骨和髋臼转移的乳腺癌患者进行了回顾性分析，旨在确定放射治疗在骨转移管理中的作用。共有97处骨病变接受了放射治疗作为初始治疗方式。7例患者初诊时即有病理性骨折，2例在接受放射治疗期间发生持续性骨折，2例在放射治疗结束后发生骨折。所有患者的疼痛均得到缓解，身体状况有所改善。三分之一的患者有骨愈合的影像学证据。在许多医疗中心通常可能需要进行预防性骨科固定的高危病变中，没有一例在放射治疗结束后发生病理性骨折。我们得出结论，放射治疗用于乳腺癌患者骨转移的初始管理通常是有效的，并且在大多数情况下不需要进行预防性手术干预。
