Jemec B
Cancer. 1980 Apr 15;45(8):2138-48. doi: 10.1002/1097-0142(19800415)45:8<2138::aid-cncr2820450822>3.0.co;2-e.
The influence of hypophysectomy, triiodothyronine (T3), and thyroxine (T4) on the goitrogenic and tumorigenic activity of methylthiouracil (MTU) and 1-methyl-2-mercapto imidazol (MMI) was studied in rats. Hypophysectomy effectively prevented the development of thyroid hyperplasia and adenomas in MTU-treated animals. T3 reduced or abolished the weight loss of goitrogen-treated animals, and prevented the development of thyroid hyperplasia, adenomas, and pulmonary metastatic nodules. The effect of T4 was less pronounced, especially in MTU-treated animals. This hormone failed to neutralize the goitrogenic effect of MTU but it did reduce significantly the incidence of thyroid adenomas and prevented the appearance of pulmonary lesions. The biological effect of the thyroid hormones correlated with their effect on the serum levels of TSH, T3, and T4. The observations are compatible with the assumption that the tumorigenic effect of the two goitrogens depends upon a state of imbalance between TSH and T3.
在大鼠中研究了垂体切除术、三碘甲状腺原氨酸（T3）和甲状腺素（T4）对甲硫氧嘧啶（MTU）和1-甲基-2-巯基咪唑（MMI）的致甲状腺肿和致瘤活性的影响。垂体切除术有效预防了MTU处理动物的甲状腺增生和腺瘤的发展。T3减少或消除了致甲状腺肿药物处理动物的体重减轻，并预防了甲状腺增生、腺瘤和肺转移结节的发展。T4的作用不太明显，尤其是在MTU处理的动物中。这种激素未能中和MTU的致甲状腺肿作用，但确实显著降低了甲状腺腺瘤的发生率并预防了肺部病变的出现。甲状腺激素的生物学效应与其对血清促甲状腺激素（TSH）、T3和T4水平的影响相关。这些观察结果与以下假设一致，即两种致甲状腺肿药物的致瘤作用取决于TSH和T3之间的失衡状态。
