Jemec B
Cancer. 1977 Nov;40(5):2188-202. doi: 10.1002/1097-0142(197711)40:5<2188::aid-cncr2820400529>3.0.co;2-o.
The nature of tumors appearing in the thyroid gland and in the lungs of mice fed two standard goitrogenic drugs (MTU and MII) has been studied. These tumors have been considered malignant on the basis of their morphological appearance and their occurrence in abnormal locations. Some investigatiors, however, have questioned that they are actually malignant. The present results indicate that these tumors are most likely not malignant even if it is shown that the pulmonary nodules are of thyroid origin. The thyroid adenomas disappear once the goitrogen is withdrawn, but thryoid enlargement pesists, and event 6 months after discontinuation of the goitrogenic treatment , pulmonary nodules are still produced. Evidence is presented that these nodules are emoli from hyperplastic thyroid tissue and not tumors.
对喂食两种标准致甲状腺肿药物（MTU和MII）的小鼠甲状腺和肺部出现的肿瘤性质进行了研究。基于其形态外观及其在异常位置的出现，这些肿瘤被认为是恶性的。然而，一些研究人员质疑它们实际上是否为恶性。目前的结果表明，即使已证明肺结节起源于甲状腺，这些肿瘤很可能也不是恶性的。一旦停用致甲状腺肿药物，甲状腺腺瘤就会消失，但甲状腺肿大仍会持续，并且在停止致甲状腺肿治疗6个月后，仍会产生肺结节。有证据表明，这些结节是增生性甲状腺组织的栓子而非肿瘤。
