Yates J W, Chalmer B, McKegney F P
Cancer. 1980 Apr 15;45(8):2220-4. doi: 10.1002/1097-0142(19800415)45:8<2220::aid-cncr2820450835>3.0.co;2-q.
The Karnofsky Performance Status Scale (KPS) was designed to measure the level of patient activity and medical care requirements. It is a general measure of patient independence and has been widely used as a general assessment of patient with cancer. Although there is a long history of use of the KPS for judging cancer patients, its reliability and validity have been assumed without formal investigation. The interrater reliability of the KPS was investigated in two ways, both of which gave evidence of moderately high reliability. The patients evaluated in their home were usually assigned a lower KPS score compared with a similar evaluation at the same time done in the outpatient clinic. Costruct validity of the KPS was demonstrated by strong correlation with several variables relating to physical function. On-study KPS score accurately predicted early death, but high initial KPS scores did not necessarily predict long survival. Patient deterioration with subsequent death within a few months could be predicted to a limited extent by a rapidly dropping KPS. These results suggest that the KPS has considerable validity as a global indicator of the functional status of patients with cancer and might be helpful for following other patients with chronic disease.
卡诺夫斯基功能状态量表（KPS）旨在衡量患者的活动水平和医疗护理需求。它是对患者独立性的一种综合衡量，已被广泛用作癌症患者的综合评估指标。尽管KPS用于评判癌症患者已有很长历史，但一直是在未经正式调查的情况下假定其可靠性和有效性的。KPS的评分者间信度通过两种方式进行了调查，两种方式均提供了中等高度信度的证据。与在门诊同时进行的类似评估相比，在家中接受评估的患者通常被赋予较低的KPS评分。KPS的结构效度通过与几个与身体功能相关的变量的强相关性得到了证明。研究期间的KPS评分准确预测了早期死亡，但初始KPS高分不一定能预测长期生存。KPS迅速下降在一定程度上可以预测患者在几个月内病情恶化并随后死亡。这些结果表明，KPS作为癌症患者功能状态的整体指标具有相当的效度，可能有助于跟踪其他慢性病患者。
