Pergolizzi R G, Grunberger D
Cancer Lett. 1980 Feb;8(4):329-33. doi: 10.1016/0304-3835(80)90149-4.
In contrast to normal eukaryotic tissue, which contains a single isoaccepting species of tRNAPhe, the Ehrlich ascites carcinoma contains a spectrum of tRNAPhe species varying in their relative degree of posttranscriptional modification. The occurrence of multiple species involves an incomplete biosynthesis of the Y base, a complex hypermodified nucleoside located adjacent to the 3' end of the anticodon. Following intraperitoneal innoculation of a mixture of essential amino acids and vitamins into these mice, the majority of the tumor tRNAPhe behaved like the single liver tRNAPhe species. This suggests that under these conditions the modification of Y base was completed.
与含有单一同功接受体种类的苯丙氨酸tRNA的正常真核组织相反，艾氏腹水癌含有一系列苯丙氨酸tRNA种类，它们的转录后修饰相对程度各不相同。多种种类的出现涉及Y碱基的不完全生物合成，Y碱基是一种复杂的超修饰核苷，位于反密码子3'端附近。在向这些小鼠腹腔内接种必需氨基酸和维生素的混合物后，大多数肿瘤苯丙氨酸tRNA的行为类似于肝脏中单一的苯丙氨酸tRNA种类。这表明在这些条件下，Y碱基的修饰完成了。
