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Changes of post-transcriptional modification of wye base in tumor-specific tRNAPhe.

作者信息

Kuchino Y, Borek E, Grunberger D, Mushinski J F, Nishimura S

出版信息

Nucleic Acids Res. 1982 Oct 25;10(20):6421-32. doi: 10.1093/nar/10.20.6421.

DOI:10.1093/nar/10.20.6421
PMID:6924749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC326932/
Abstract

Nucleotide sequences of normal mouse liver tRNAPhe and tumor-specific tRNAPhes isolated from Ehrlich ascites tumor and neuroblastoma cells were examined by post-labeling techniques. The results showed that their sequences are identical, except for changes in post-transcriptional modifications that are located in the anticodon region. Normal mouse liver tRNAPhe contained Cm32, Gm34 and YOH37. On the other hand, tumor-specific tRNAPhes were found in one of two possible configurations: 1) Cm32, Gm34 and YOH37 (under-modified YOH) or 2) C32, G34 and m1G37. The ratio of the two forms of tRNAPhes differed in different tumor cells; Ehrlich ascites tumor tRNAPhe had mainly YOH-containing tRNAPhe whereas neuroblastoma tRNAPhe has predominantly m1G-containing tRNAPhe. It was concluded that tumor-specific tRNAPhes are products of different extents of modification, rather than of new tRNA transcription.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1aa/326932/a1a7db5aadab/nar00389-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1aa/326932/28ae44106aac/nar00389-0202-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1aa/326932/4433260b3651/nar00389-0203-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1aa/326932/4209e3a37388/nar00389-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1aa/326932/a1a7db5aadab/nar00389-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1aa/326932/28ae44106aac/nar00389-0202-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1aa/326932/4433260b3651/nar00389-0203-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1aa/326932/4209e3a37388/nar00389-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1aa/326932/a1a7db5aadab/nar00389-0206-a.jpg

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Changes of post-transcriptional modification of wye base in tumor-specific tRNAPhe.
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本文引用的文献

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Cancer Lett. 1980 Feb;8(4):329-33. doi: 10.1016/0304-3835(80)90149-4.
2
Compilation of tRNA sequences.转运RNA序列的汇编。
Nucleic Acids Res. 1982 Jan 22;10(2):r1-55.
3
Biological and structural differences between tRNAVal species isolated from rat ascites hepatoma cells and normal rat liver.从大鼠腹水肝癌细胞和正常大鼠肝脏中分离出的缬氨酸转运核糖核酸（tRNAVal）物种之间的生物学和结构差异。
Wiley Interdiscip Rev RNA. 2022 Jul;13(4):e1700. doi: 10.1002/wrna.1700. Epub 2021 Oct 19.
4
Modifications of the human tRNA anticodon loop and their associations with genetic diseases.人 tRNA 反密码子环的修饰及其与遗传疾病的关联。
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