Steiner P, Rao M, Victoria M, James P
Clin Pediatr (Phila). 1980 Jun;19(6):389-1. doi: 10.1177/000992288001900602.
Forty-one children suspected of having tuberculosis were simultaneously given an intermediate strength Mantoux test, an old tuberculin tine test (OT), and a purified protein derivative (PPD) tine test. Each test was read at 48 hours, and the largest diameter of induration was recorded. Twenty-nine patients had a positive reaction to the Mantoux test, 20 patients had a positive reaction to the OT tine test, and 16 patients had a positive reaction to the PPD-tine test. There were seven instances of a doubtful reaction to the OT tine test and nine to the PPD-tine test. Two children with positive Mantoux tests had negative OT tine tests, and four with positive Mantoux tests had negative PPD-tine test reactions. There was a significant difference between the number of positive reactors to the Mantoux test and both tine tests. If all tine test reactions of 2 mm or more were considered positive (doubtful plus positive reactors), there was no significant difference between any of the tuberculin tests. All suggestively positive tine reactors should, therefore, be retested with a Mantoux test to avoid false-negative interpretation of the tines.
41名疑似患有结核病的儿童同时接受了中等强度的结核菌素皮内试验、旧结核菌素划痕试验（OT）和纯化蛋白衍生物（PPD）划痕试验。每项试验均在48小时后读取结果，并记录硬结的最大直径。29名患者结核菌素皮内试验呈阳性反应，20名患者旧结核菌素划痕试验呈阳性反应，16名患者PPD划痕试验呈阳性反应。旧结核菌素划痕试验有7例反应可疑，PPD划痕试验有9例。2名结核菌素皮内试验呈阳性的儿童旧结核菌素划痕试验呈阴性，4名结核菌素皮内试验呈阳性的儿童PPD划痕试验呈阴性反应。结核菌素皮内试验阳性反应者的数量与两种划痕试验之间存在显著差异。如果将所有2毫米或以上的划痕试验反应视为阳性（可疑加阳性反应者），则任何一种结核菌素试验之间均无显著差异。因此，所有提示性阳性的划痕试验反应者均应再次进行结核菌素皮内试验，以避免对划痕试验的假阴性解读。
