苯妥英治疗期间达到稳态血清浓度时间的列线图估计

Nomographic estimation of time to reach steady-state serum concentration during phenytoin therapy.

作者信息

Vozeh S, Follath F

出版信息

Eur J Clin Pharmacol. 1980 Jan;17(1):33-5. doi: 10.1007/BF00561674.

Abstract

The time to reach steady-state on phenytoin therapy depends on the dose and the pharmacokinetic parameter of the individual patient. A nomogram is presented to help the physician to decide whether a measured serum concentration of phenytoin can be regarded as being within 20% of the steady-state level. The nomogram is based on the pharmacokinetic parameters of phenytoin reported for adult patients.

摘要

苯妥英治疗达到稳态的时间取决于剂量和个体患者的药代动力学参数。现提供一张列线图，以帮助医生判断所测得的苯妥英血清浓度是否可被视为在稳态水平的20%范围内。该列线图基于已报道的成年患者苯妥英药代动力学参数。