给予去氧皮质酮可增加大鼠肾脏磷脂酶活性。
DOCA administration increases renal phospholipase activity in the rat.
作者信息
Baggio B, Bordin D, de Giorgi G, Favaro S, Antonello A, Borsatti A
出版信息
Experientia. 1980 Mar 15;36(3):366-7. doi: 10.1007/BF01952330.
PMID:7371801
Abstract
The phospholipase activity of renal tissue has been evaluated in controls and in DOCA treated rats. DOCA treated animal showed a higher than normal enzyme activity. Since a phospholipase is the key step in prostaglandin biosynthesis, it is suggested that the increased prostaglandin release promoted by mineraloactive steroids is mediated by an activation of this key enzyme.
摘要
已在对照组和接受去氧皮质酮（DOCA）治疗的大鼠中评估了肾组织的磷脂酶活性。接受DOCA治疗的动物显示出高于正常水平的酶活性。由于磷脂酶是前列腺素生物合成中的关键步骤，因此有人提出，盐皮质活性类固醇促进的前列腺素释放增加是由这种关键酶的激活介导的。
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