Chang T W, Gorbach S L, Bartlett J G, Saginur R
Gastroenterology. 1980 Jun;78(6):1584-6.
Four cases of antibiotic-associated colitis and diarrhea caused by Clostridium difficile were successfully treated with oral bacitracin, 25,000 units four times daily for 7-10 days. Diarrhea resolved in all of the cases, in 2 days, with disappearance of Clostridium difficile toxin in the stools in 3 out of 4 patients so measured. Two of the patients treated had relapses after vancomycin, while the other 2 were experiencing the first episodes. One patient relapsed after bacitracin treatment, but was treated successfully with vancomycin. Our preliminary experience indicates that bacitracin, being less expensive and more readily available world-wide than vancomycin, could be used as an alternative drug for toxin-induced colitis or diarrhea.
4例由艰难梭菌引起的抗生素相关性结肠炎和腹泻患者，通过口服杆菌肽成功治愈，剂量为每日4次，每次25,000单位，持续7至10天。所有病例的腹泻均在2天内得到缓解，在接受检测的4例患者中，有3例粪便中艰难梭菌毒素消失。接受治疗的患者中有2例在使用万古霉素后复发，另外2例为首次发作。1例患者在使用杆菌肽治疗后复发，但使用万古霉素成功治愈。我们的初步经验表明，杆菌肽比万古霉素价格更低且在全球范围内更容易获得，可作为毒素诱导的结肠炎或腹泻的替代药物。
