Fouque F, Joseph D, Vargaftig B B
Agents Actions. 1982 Dec;12(5-6):720-2. doi: 10.1007/BF01965091.
The mode of action of PAF-acether on human and rabbit plasma-free platelets is reviewed. PAF-acether and adrenaline synergize to trigger aggregation of human platelets, and this synergism is refractory to aspirin. When degranulated rabbit platelets are stimulated with PAF-acether, with thrombin or with the snake venom component convulxin, aggregation is obtained in the absence of detectable secretion. Collagen-induced aggregation is reduced, and is suppressed when aspirin is applied to the degranulated platelets. The formation of PAF-acether by platelets, and their stimulation by PAF-acether itself, should be added to the newly recognized pathways for platelet stimulation.
本文综述了血小板活化因子（PAF-乙醚）对人和兔无血浆血小板的作用方式。PAF-乙醚与肾上腺素协同作用，触发人血小板聚集，且这种协同作用不受阿司匹林影响。当用PAF-乙醚、凝血酶或蛇毒成分convulxin刺激脱颗粒的兔血小板时，在未检测到分泌的情况下即可发生聚集。胶原蛋白诱导的聚集减少，当对脱颗粒血小板应用阿司匹林时，聚集受到抑制。血小板PAF-乙醚的形成及其自身受PAF-乙醚的刺激，应添加到新认识的血小板刺激途径中。
