[蜂毒中蜂毒肽对线粒体功能的影响]
[Effect of melitten from bee venom on mitochondrial functions].
作者信息
Shkinev A V, Gagel'gans A I, Tashmukhamedov B A, Miroshnikov A I
出版信息
Biokhimiia. 1978 Aug;43(8):1452-7.
Effect of different concentrations of bee venom melittin on respiration, mitochondrial oxidative phosphorylation, and permeability of mitochondrial inner membranes for different ions is studied. Low melittin concentrations (1-2 mcM) increased in several times the rate of H+, K+, Na+ ions and Tris transport, in a lesser degree--bivalent ions and Cl- transport and did not affect the permeability for succrose. Thus, the uncoupling effect of low melittin concentrations on mitochondrial energetic apparatus is due to unspecific increase of inner membrane permeability. High melittin concentrations (50-100 mcM) inhibited mitochondrial respiration due to disturbances of membrane and organized respication complexes structures.
研究了不同浓度的蜂毒溶血肽对呼吸、线粒体氧化磷酸化以及线粒体内膜对不同离子的通透性的影响。低浓度的蜂毒溶血肽（1 - 2 μM）使H⁺、K⁺、Na⁺离子和Tris的转运速率提高了数倍，对二价离子和Cl⁻的转运影响较小，且不影响蔗糖的通透性。因此，低浓度蜂毒溶血肽对线粒体能量装置的解偶联作用是由于内膜通透性的非特异性增加。高浓度的蜂毒溶血肽（50 - 100 μM）由于膜和有组织的呼吸复合体结构受到干扰而抑制线粒体呼吸。
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