Vadas P, Hay J B
Int Arch Allergy Appl Immunol. 1980;62(2):142-51. doi: 10.1159/000232506.
A nonlymphokine mediator of hyperemia has been shown to be secreted by both rabbit peritoneal exudate cells stimulated with 5% glycogen and by concanavalin A treated cells from afferent lymph of sheep. This mediator is not stored in an active form in cells, but is either activated or synthesized de novo in response to antigenic or mitogenic stimuli. Secretion of the mediator is inhibited by culturing cells in the presence of dexamethasone but not indomethacin. However, expression of the activity is inhibited by pretreatment of the assay animals with indomethacin, suggesting a two-step induction of hyperemia. A similar mediator was found to be secreted by sheep and rabbit alveolar lavage cells, and rat peritoneal exudate cells. The presence of this hyperemia-inducing activity from diverse species suggests a fundamental role in controlling blood flow. Alteration of blood flow may modulate delivery of blood-borne cells and factors to sites of chronic inflammation.
一种非淋巴因子介导的充血已被证明可由用5%糖原刺激的兔腹膜渗出细胞以及用伴刀豆球蛋白A处理的绵羊传入淋巴中的细胞分泌。这种介质在细胞中不是以活性形式储存，而是在抗原或促有丝分裂刺激下被激活或重新合成。在地塞米松存在下培养细胞可抑制介质的分泌，但吲哚美辛不能。然而，用吲哚美辛预处理试验动物可抑制该活性的表达，提示充血诱导分两步进行。发现绵羊和兔肺泡灌洗细胞以及大鼠腹膜渗出细胞也分泌类似的介质。来自不同物种的这种充血诱导活性的存在表明其在控制血流中起基本作用。血流改变可能调节血源性细胞和因子向慢性炎症部位的输送。
