Experiments in mice and rats on the induction of joint lesions following injections of serum and in chronic virus infection.

Rats and mice, in contrast to rabbits, appeared to be insusceptible to the development of rheumatoid-like joint lesions on repeated injections with bovine serum--the serum sickness model. Persistent infection of mice with the lactic dehydrogenase virus likewise failed to induce joint lesions.