Smith J C, Mitzner W
J Appl Physiol Respir Environ Exerc Physiol. 1980 Mar;48(3):450-67. doi: 10.1152/jappl.1980.48.3.450.
The pressure-volume behavior of intraparenchymal extra-alveolar arteries and veins was measured at various lung inflation states by inflating and deflating the vasculatures with air. The vascular volumes at specific vascular pressures (Pv) and transpulmonary pressures (Ptp) were partitioned into components of axial length and cross-sectional area. An analysis of the interrelationships between the perivascular pressure (Px), the vascular pressure vs. cross-sectional area behavior, and the Ptp is presented. For in vivo values of Pv, at functional residual capacity, the vascular-parenchymal mechanical interaction was small and values of arterial and venous Px approximately Ppl. With increasing Ptp to 30 cmH2O, values of both the arterial and venous Px relative to Ppl (Px - Ppl) decreased to approximately -5 cmH2O, indicating that the magnitude of the vascular-parenchymal interaction with increasing Ptp is similar for both arteries and veins in the in vivo state. At any fixed Ptp, values of arterial and venous Px - Ppl decreased nearly linearly with decreasing vascular cross-sectional area. These results were generally consistent with a linear continuum elasticity solution relating stress and deformation in the perivascular parenchyma.
通过向血管内充气和放气，在不同的肺膨胀状态下测量实质内肺泡外动脉和静脉的压力-容积行为。将特定血管压力（Pv）和跨肺压（Ptp）下的血管容积划分为轴向长度和横截面积的组成部分。本文分析了血管周围压力（Px）、血管压力与横截面积行为以及Ptp之间的相互关系。对于功能残气量时的体内Pv值，血管-实质机械相互作用较小，动脉和静脉Px值约等于胸膜腔内压（Ppl）。随着Ptp增加至30 cmH₂O，相对于Ppl的动脉和静脉Px值（Px - Ppl）均降至约-5 cmH₂O，表明在体内状态下，随着Ptp增加，动脉和静脉的血管-实质相互作用强度相似。在任何固定的Ptp下，动脉和静脉的Px - Ppl值随血管横截面积减小而近似线性下降。这些结果总体上与血管周围实质中应力和变形关系的线性连续弹性解一致。
