Lai-Fook S J, Conhaim R L
Ann Biomed Eng. 1987;15(2):173-82. doi: 10.1007/BF02364052.
The mechanical properties of the perivascular interstitium surrounding large pulmonary blood vessels are defined in terms of interstitial fluid pressure, interstitial compliance, and interstitial hydraulic resistance. Interstitial pressure is one of the main forces which determine liquid filtration across the microvascular barrier. Interstitial compliance is a measure of the ability of the interstitium to swell with hydration which increases interstitial pressure and reduces the filtration rate. Interstitial pressure and compliance are functions of the elastic properties of the surrounding lung parenchyma and the vessel wall. Solid continuum mechanics are used to describe the behavior of the lung parenchyma. The transport properties of the interstitium are described in terms of a porous material whose fluid resistance is determined by a permeability constant. The dynamics of interstitial fluid are governed by the coupling of the flow with the elastic environment. An electrical analog model is developed to predict the growth of interstitial fluid cuffs during edema formation.
围绕大型肺血管的血管周围间质的力学特性是根据间质液压力、间质顺应性和间质水力阻力来定义的。间质压力是决定液体通过微血管屏障滤过的主要力量之一。间质顺应性是间质随水化膨胀能力的一种度量，水化会增加间质压力并降低滤过率。间质压力和顺应性是周围肺实质和血管壁弹性特性的函数。固体连续介质力学用于描述肺实质的行为。间质的传输特性是根据一种多孔材料来描述的，其流体阻力由渗透常数决定。间质液的动力学受流体与弹性环境耦合的支配。开发了一个电模拟模型来预测水肿形成期间间质液袖套的生长。
