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自发性高血压大鼠和正常血压大鼠的双向穿梭箱实验及按压杠杆回避实验

Two-way shuttle box and lever-press avoidance in the spontaneously hypertensive and normotensive rat.

作者信息

Sutterer J R, Perry J, DeVito W

出版信息

J Comp Physiol Psychol. 1980 Feb;94(1):155-63. doi: 10.1037/h0077649.

DOI:10.1037/h0077649
PMID:7372850
Abstract

These experiments characterized behaviorally two strains of rat that have been selectively bred for blood pressure differences. Avoidance performances of the spontaneously hypertensive rat (SHR) and normotensive rat (WKYN) were examined under two conditions: a discrete-trial two-way shuttle box avoidance procedure and a discrete-trial lever-press avoidance procedure. The WKYN strain reached a higher level of acquisition in the two-way shuttle box task than the SHR strain, but this difference was confounded by an initial difference in pretest avoidance rate. In contrast, the SHR strain was superior in the lever-press avoidance procedure under all conditions employed. These data are interpreted as being consistent with a hypothesis offered by Satinder that strains selectively bred for some behavioral feature may also differ in central arousal which will interact with task difficulty to determine performance differences. The data clearly indicate that the selective breeding for high and low blood pressure has simultaneously influenced the behavioral properties of these two strains.

摘要

这些实验从行为学角度对两组因血压差异而进行选择性培育的大鼠品系进行了特征描述。在两种条件下检测了自发性高血压大鼠(SHR)和正常血压大鼠(WKYN)的回避行为表现:一种是离散试验双向穿梭箱回避程序,另一种是离散试验杠杆按压回避程序。在双向穿梭箱任务中,WKYN品系比SHR品系达到了更高的习得水平,但这种差异因预测试回避率的初始差异而混淆。相比之下,在所有采用的条件下,SHR品系在杠杆按压回避程序中表现更优。这些数据被解释为与萨廷德提出的假设一致,即因某些行为特征而进行选择性培育的品系在中枢唤醒方面也可能存在差异,这将与任务难度相互作用以决定表现差异。数据清楚地表明,对高、低血压的选择性培育同时影响了这两个品系的行为特性。

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Two-way shuttle box and lever-press avoidance in the spontaneously hypertensive and normotensive rat.自发性高血压大鼠和正常血压大鼠的双向穿梭箱实验及按压杠杆回避实验
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