Young W, DeCrescito V, Tomasula J J, Ho V
J Neurosurg. 1980 Apr;52(4):473-81. doi: 10.3171/jns.1980.52.4.0473.
Spinal cord injury consistently evokes a transient 3- to 4-minute rise is systemic pressure, followed by prolonged hypotension. Because the role of the sympathetic nervous system in these blood pressure changes is not clear, the pressure responses were studied using systematic ablation of the peripheral sympathetic nervous system. In total, 24 cats were subjected to bilateral thoracic sympathectomy, adrenalectomy, splanchnicectomy, combinations of the preceding, sham operation, or no treatment. Either 3 or 24 hours after the ablations, the blood pressure responses were evoked by 400 gm-cm contusions of the thoracic cord. Although neither thoracic sympathectomy nor adrenalectomy alone abolished the hypertensive phase, the combination of the two procedures did. This suggests that both the thoracic sympathetic ganglia and the adrenal glands participate in the pressor response. Thoracic sympathectomy affected primarily the early part, whereas adrenalectomy diminished the later part of the hypertensive response. This correlates with the function of the former being neurally and the latter being humorally mediated. None of the sympathetic lesions consistently affected the hypotensive phase. Spinal contusion injury produces widespread sympathetic activation, mediating the hypertensive changes.
脊髓损伤始终会引起全身性血压短暂升高3至4分钟，随后是长时间的低血压。由于交感神经系统在这些血压变化中的作用尚不清楚，因此通过系统性切除外周交感神经系统来研究压力反应。总共24只猫接受了双侧胸交感神经切除术、肾上腺切除术、内脏神经切除术、上述手术的组合、假手术或不治疗。在切除术后3或24小时，通过对胸段脊髓进行400克 - 厘米的挫伤来诱发血压反应。虽然单独的胸交感神经切除术或肾上腺切除术都不能消除高血压阶段，但这两种手术的联合却可以。这表明胸交感神经节和肾上腺都参与了升压反应。胸交感神经切除术主要影响早期部分，而肾上腺切除术则减弱了高血压反应的后期部分。这与前者由神经介导而后者由体液介导的功能相关。没有一种交感神经损伤能持续影响低血压阶段。脊髓挫伤损伤会引起广泛的交感神经激活，介导高血压变化。
