Rawe S E, Perot P L
J Neurosurg. 1979 Jan;50(1):58-63. doi: 10.3171/jns.1979.50.1.0058.
Experimental contusion paraplegic injury to the posterior spinal cord in cats results in a sudden increase of systemic blood pressure to between 200 and 250 mm Hg, and an increase in pulse pressure and a slowing of pulse rate. This initial hypertensive phase lasts approximately 3 to 4 minutes, and then is followed by a hypotensive phase. This pressor response is mediated by the alpha adrenergic receptor sites of the peripheral sympathetic nervous system and can be blocked by intravenous phenoxybenzamine, an alpha adrenergic blocking agent. The hypotensive phase is the result of an overall reduction in alpha adrenergic vascular tone and can be reversed by the infusion of metaraminol or intravenous fluids. The alterations in blood pressure that follow impact injury are most likely related to alterations of peripheral arteriolar resistance and venous return of blood to the heart.
对猫的脊髓后部进行实验性挫伤性截瘫损伤会导致全身血压突然升高至200至250毫米汞柱之间，脉压增加，脉搏率减慢。这个初始高血压阶段持续约3至4分钟，然后是低血压阶段。这种升压反应由外周交感神经系统的α肾上腺素能受体介导，可被α肾上腺素能阻滞剂苯氧苄胺静脉注射阻断。低血压阶段是α肾上腺素能血管张力全面降低的结果，可通过去甲肾上腺素或静脉输液逆转。撞击伤后血压的变化很可能与外周小动脉阻力和静脉回心血量的改变有关。
