Troutner D E, Simon J, Ketring A R, Volkert W, Holmes R A
J Nucl Med. 1980 May;21(5):443-8.
The macrocyclic amine, cyclam, has been found to be an efficient complexing agent for Tc-99m. Complexes can be formed in yields of higher than 95% at pH 11 in 10(-3) M cyclam using 5 x 10(-6) M SnC4H4O6 as a reducing agent. The complex is positively charged and is stable in air. It is not decomposed by dilution, by 0.05 M NaOH, or 0.05 M H2O2, but does show slight decomposition in 0.05 M HCl. In unanesthetized mice the complex is cleared rapidly from the blood by the kidneys and liver. Preliminary studies show that derivatives of cyclam also complex Tc-99m.
已发现大环胺环胺是一种用于锝-99m的有效络合剂。使用5×10⁻⁶ M的SnC₄H₄O₆作为还原剂，在10⁻³ M环胺中于pH 11时可形成产率高于95%的络合物。该络合物带正电荷，在空气中稳定。它不会因稀释、0.05 M的NaOH或0.05 M的H₂O₂而分解，但在0.05 M的HCl中会有轻微分解。在未麻醉的小鼠中，该络合物通过肾脏和肝脏从血液中迅速清除。初步研究表明，环胺的衍生物也能与锝-99m络合。
