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99mTc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical.

作者信息

Volkert W A, Hoffman T J, Seger R M, Troutner D E, Holmes R A

出版信息

Eur J Nucl Med. 1984;9(11):511-6. doi: 10.1007/BF00263256.

DOI:10.1007/BF00263256
PMID:6394334
Abstract

Propylene amine oxime (PnAO) forms a neutral lipid soluble complex with 99mTc. 99mTc-PnAO can be prepared by simple reduction of 99mTc-pertechnetate with stannous ion in the presence of excess PnAO in saline at or near neutral pH. This agent will passively penetrate biological membranes including the intact blood-brain barrier (BBB) as evidenced by the high brain uptake observed shortly after IV injection. The first-pass extraction efficiency in baboons was estimated to be 80% at normal blood flow. This agent or a derivatized form of 99mTc-PnAO may be useful in assessment of regional cerebral blood flow (rCBF) in humans.

摘要

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Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems.用锝-99m进行放射性标记以研究高容量和低容量生化系统。
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99mTc-HMPAO as a tumour blood flow agent.
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99mTc-HM-PAO for leukocyte labeling--experimental comparison with 111In oxine in dogs.用于白细胞标记的99mTc-HM-PAO——与犬体内111In奥克辛的实验比较
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The behavior of 99mTc-hexamethylpropyleneamineoxime (99mTc-HMPAO) in blood and brain.
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Comparative evaluation of SPECT, CT and CW Doppler data in patients with ischemic lesions of the brain.脑缺血性病变患者中SPECT、CT及连续波多普勒数据的对比评估
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Determination of cerebral perfusion by means of planar brain scintigraphy and 99mTc-HMPAO in brain death, persistent vegetative state and severe coma.通过平面脑闪烁显像术和99mTc-HMPAO测定脑死亡、持续性植物状态和重度昏迷患者的脑灌注情况。
Intensive Care Med. 1992;18(2):76-81. doi: 10.1007/BF01705036.
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Regional intracellular pH shift: a proposed new mechanism for radiopharmaceutical uptake in brain and other tissues.区域细胞内pH值变化：一种关于放射性药物在脑和其他组织中摄取的新机制假说。
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Initial experience with SPECT (single-photon computerized tomography) of the brain using N-isopropyl I-123 p-iodoamphetamine: concise communication.
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Regional cerebral blood flow in stroke by 133Xenon inhalation and emission tomography.
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Quantifying local cerebral blood flow by N-isopropyl-p-[123I]iodoamphetamine (IMP) tomography.通过 N-异丙基-p-[123I]碘安非他明（IMP）断层扫描定量局部脑血流量。
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