Ford W D, MacKellar A, Richardson C J
J Pediatr Surg. 1980 Apr;15(2):160-3. doi: 10.1016/s0022-3468(80)80008-x.
Children suspected of having appendicitis were treated with preoperative metronidazole per rectum and then postoperative metronidazole per rectum until the drug could be administered orally. This series shows that even when administered after anesthetic induction, an adequate blood level of metronidazole was achieved at surgery. Other antibiotics were not used even when there was peritonitis. The wound infection rate in this small series was low, when compared to other series and our own comparison group.
疑似患有阑尾炎的儿童术前经直肠给予甲硝唑，术后继续经直肠给予甲硝唑，直至可以口服该药。本系列研究表明，即使在麻醉诱导后给药，手术时甲硝唑也能达到足够的血药浓度。即使存在腹膜炎，也未使用其他抗生素。与其他系列研究以及我们自己的对照组相比，这个小系列中的伤口感染率较低。
