Wright J E
Aust N Z J Surg. 1982 Apr;52(2):127-9. doi: 10.1111/j.1445-2197.1982.tb06085.x.
A reduction in wound infection after appendicectomy for acute appendicitis in children is described and attributed to the use of preoperative prophylactic antibiotics. In 118 consecutive children with appendicitis proven on histological examination there were three wound infections (2.5%) and only one of these was a serious wound abscess (0.8%). There was no postoperative abdominal abscess. Twenty-four of these children had appendicitis complicated by gangrene, perforation, peritonitis or abscess formation. This wound infection rate is compared with the author's previous unpublished rate of 8%, and a rate of 37% in a previously published series. It is comparable to the current wound infection rate for clean heriniorrhaphy procedures. The ideal is a single antibiotic effective against aerobic and anaerobic organisms with few side effects and little hypersensitivity. In early appendicitis, cefoxitin alone is likely to be effective, but in patients with complicated appendicitis, cefoxitin with metronidazole or lincomycin with an aminoglycoside are recommended.
据报道，儿童急性阑尾炎阑尾切除术后伤口感染率降低，这归因于术前预防性使用抗生素。在118例经组织学检查证实为阑尾炎的连续患儿中，有3例伤口感染（2.5%），其中只有1例是严重的伤口脓肿（0.8%）。没有术后腹腔脓肿。这些患儿中有24例阑尾炎合并坏疽、穿孔、腹膜炎或脓肿形成。将该伤口感染率与作者之前未发表的8%的感染率以及之前发表系列中的37%的感染率进行了比较。它与目前清洁疝修补手术的伤口感染率相当。理想的情况是使用一种对需氧菌和厌氧菌均有效的抗生素，副作用少且过敏反应小。在早期阑尾炎中，单独使用头孢西丁可能有效，但对于复杂阑尾炎患者，建议使用头孢西丁联合甲硝唑或林可霉素联合氨基糖苷类药物。
