Gold G, Duvall R N, Palermo B T
J Pharm Sci. 1980 Apr;69(4):384-6. doi: 10.1002/jps.2600690405.
New instrumentation to measure the flexure breaking strength of capsule-shaped tablets was developed. It consisted of a mechanical linkage to apply the breaking load at a uniform rate and a strain-gauge instrumented cantilever beam to convert the load to a proportional millivolt response on a recorder. A recorder tracing was obtained of increasing load with time, with a break in the tracing denoting the tablet's flexure breaking strength. Measurements were made for different tablet hardnesses, and a plot of tablet hardness versus flexure breaking strength yielded a profile of the mechanical strength of the tablet. The instrumentation was shown to have application for determining the effects of tablet thicknesses, tablet ingredients, tablet sizes, cup depths, and bisect dimensions on tablet strength.
开发了一种用于测量胶囊形片剂挠曲断裂强度的新型仪器。它由一个以均匀速率施加断裂载荷的机械连杆机构和一个应变片式悬臂梁组成，该悬臂梁将载荷转换为记录仪上成比例的毫伏响应。得到了载荷随时间增加的记录仪跟踪曲线，跟踪曲线中的断点表示片剂的挠曲断裂强度。对不同片剂硬度进行了测量，绘制了片剂硬度与挠曲断裂强度的关系图，得到了片剂机械强度的分布图。结果表明，该仪器可用于确定片剂厚度、片剂成分、片剂尺寸、杯深和二等分尺寸对片剂强度的影响。
