Soci M M, Parrott E L
J Pharm Sci. 1980 Apr;69(4):403-6. doi: 10.1002/jps.2600690410.
Nitrofurantoin, 200 mg, was administered orally to 11 subjects in an aqueous reference dispersion and in five suspensions having the same rheogram. Algin, carbomer, guar gum, methylcellulose, and colloidal magnesium aluminum silicate were the five suspending agents employed. Complexation was demonstrated by dialysis between nitrofurantoin and methylcellulose and between nitrofurantoin and carbomer; however, physiological availability was not altered by the interaction. The viscosity increase slowed absorption and urinary excretion, thus delaying the time of the maximum excretion rate without a decrease in bioavailability. A clinically acceptable urinary nitrofurantoin concentration was maintained for at least 2 hr longer by a viscosity increase.
将200毫克呋喃妥因以水性参比分散体形式及在具有相同流变图的五种混悬液中口服给予11名受试者。所用的五种助悬剂分别为藻酸盐、卡波姆、瓜尔胶、甲基纤维素和胶体硅酸镁铝。已证实呋喃妥因与甲基纤维素之间以及呋喃妥因与卡波姆之间会发生络合作用；然而，这种相互作用并未改变生理可利用性。粘度增加减缓了吸收和尿排泄，从而延迟了最大排泄率出现的时间，而生物利用度并未降低。通过增加粘度，临床上可接受的尿呋喃妥因浓度至少维持延长了2小时。
