Gordon-Smith I C, Taylor E W, Nicolaides A N, Golcman L, Kenyon J R, Eastcott H H
Br J Surg. 1978 Dec;65(12):834-8. doi: 10.1002/bjs.1800651203.
A series of 245 patients was operated upon for abdominal aortic aneurysm during the years 1969-77, of whom 162 were elective cases while in 83 the aneurysm was leaking or had ruptured. The hospital mortality for the latter group fell from 77 per cent at the beginning of the study period to 30 per cent at the end. For elective operations, hospital mortality averaged 9.3 per cent, though during the last 2 years there were no deaths in the 51 consecutive cases. Operative methods and postoperative treatment changed during the years of the study, with few excision-replacement grafts and greater use of the inlay technique, most of the latter being simple unbranched Dacron tubes. Early graft infection, the most important and serious surgical complication, caused 9 deaths, an overall incidence of 3.7 per cent, of which 8 were in patients who received no perioperative antibiotics and only 1 among the patients who did receive them. All deaths were in the inlay group. The reasons for this are discussed. Since July 1976 perioperative antibiotic treatment has been routine for all arterial prosthetic graft patients in our hospital.
1969年至1977年间,对245例腹主动脉瘤患者进行了手术,其中162例为择期手术,83例动脉瘤出现渗漏或破裂。后一组患者的医院死亡率从研究初期的77%降至末期的30%。择期手术的医院死亡率平均为9.3%,不过在最后两年,连续51例手术无死亡病例。在研究期间,手术方法和术后治疗有所改变,切除-置换移植术较少,镶嵌技术的应用增多,后者大多是简单的无分支涤纶管。早期移植物感染是最重要、最严重的手术并发症,导致9例死亡,总发生率为3.7%,其中8例发生在未接受围手术期抗生素治疗的患者中,仅1例发生在接受了抗生素治疗的患者中。所有死亡病例均在镶嵌组。文中讨论了其原因。自1976年7月起,我院对所有动脉人工血管移植患者均常规进行围手术期抗生素治疗。