乌头碱诱发扭体法作为评估阿司匹林样镇痛活性的一种方法。
Aconitine-induced writhing as a method for assessing aspirin-like analgesic activity.
作者信息
Bhalla T N, Bhargava K P
出版信息
J Pharmacol Methods. 1980 Jan;3(1):9-14. doi: 10.1016/0160-5402(80)90059-5.
A painful writhing syndrome is produced by aconitine when given intraperitoneally. It is similar to that induced by other chemical agent viz. phenylquinone, acetic acid, and bradykinin. Aconitine writhing is quick to appear, shows greater frequency and longer duration than that induced by other agents. The nonnarcotic analgesics more selectively antagonize the aconitine writhing than orally-administered narcotic analgesics. Thus the aconitine writhing method is a very suitable method for the selective screening of the aspirin type of analgesic agent.
腹腔注射乌头碱可引发一种疼痛性扭体综合征。它与其他化学试剂（如苯醌、乙酸和缓激肽）所诱发的综合征相似。乌头碱诱发的扭体反应出现迅速，相较于其他试剂诱发的反应，频率更高且持续时间更长。与口服麻醉性镇痛药相比，非麻醉性镇痛药对乌头碱诱发的扭体反应具有更具选择性的拮抗作用。因此，乌头碱扭体法是一种非常适合用于选择性筛选阿司匹林类镇痛药的方法。
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