Kaplan M L, Trout J R, Smith P
Metabolism. 1980 Apr;29(4):333-9. doi: 10.1016/0026-0495(80)90006-2.
Epididymal fat pad adipocyte frequency distributions of obese (fa/fa) and nonobese (non-fa/fa) Zucker rats were determined from 2 to 20 wk of age. The fa/fa rats consistently displayed a higher proportion of larger adipocytes than the non-fa/fa rats of all ages studied. Increased adipocyte size preceded an increase in the number of adipocytes during the early phases of obese development. Among the fa/fa rats, the frequency of small cells continued to increase, which resulted in a bimodal distribution by 20 wk of age. Discriminant analysis suggests that the differences in adipocyte size frequency distributions at 2 wk of age may be another useful means to identify fa/fa and non-fa/fa pups prior to expression of overt obesity. Increased fat storage may reflect the lower energy expended by the very young fa/fa rats.
测定了肥胖（fa/fa）和非肥胖（非fa/fa） Zucker大鼠从2周到20周龄附睾脂肪垫脂肪细胞的频率分布。在所有研究年龄的fa/fa大鼠中，始终比非fa/fa大鼠显示出更高比例的较大脂肪细胞。在肥胖发展的早期阶段，脂肪细胞大小增加先于脂肪细胞数量增加。在fa/fa大鼠中，小细胞的频率持续增加，到20周龄时导致双峰分布。判别分析表明，2周龄时脂肪细胞大小频率分布的差异可能是在明显肥胖表现之前识别fa/fa和非fa/fa幼崽的另一种有用方法。脂肪储存增加可能反映了非常年幼的fa/fa大鼠消耗的能量较低。
