Johnson P R, Stern J S, Greenwood M R, Hirsch J
Metabolism. 1978 Dec;27(12 Suppl 2):1941-54. doi: 10.1016/s0026-0495(78)80011-0.
Obese female Zucker rats show persistent increases in fat cell number compared to lean female Zucker rats from 5 to 52 wk of age. The hyperplastic obesity of the Zucker rat is also accompanied by fat cell hypertrophy and elevated plasma immunoreactive insulin (IRI). Average adipocyte size reaches a peak value at 14 wk of age in the subcutaneous, retroperitoneal and parametrial depots of the female obese rat. Plasma IRI also shows a peak at 14 wk of age. In addition, at this age thymidine kinase activity, a measure of proliferative capacity in tissue, is elevated in obese compared to lean rats, and at 15 1/2 wk of age a bimodal distribution of adipocytes is present in obese rat adipose tissue. The data suggest that attainment of a critical adipocyte size accompanied by maximum levels of plasma IRI may act in concert to potentiate fat cell hyperplasia in Zucker obese rats.
与瘦型雌性 Zucker 大鼠相比，肥胖雌性 Zucker 大鼠在 5 至 52 周龄期间脂肪细胞数量持续增加。Zucker 大鼠的增生性肥胖还伴有脂肪细胞肥大和血浆免疫反应性胰岛素（IRI）升高。在雌性肥胖大鼠的皮下、腹膜后和子宫旁脂肪库中，平均脂肪细胞大小在 14 周龄时达到峰值。血浆 IRI 在 14 周龄时也出现峰值。此外，在这个年龄，与瘦鼠相比，肥胖大鼠中作为组织增殖能力指标的胸苷激酶活性升高，并且在 15.5 周龄时，肥胖大鼠脂肪组织中存在双峰分布的脂肪细胞。数据表明，达到临界脂肪细胞大小并伴有血浆 IRI 的最高水平可能共同作用，增强 Zucker 肥胖大鼠的脂肪细胞增生。
