Johnson A R, Hood R L, Emery J L
Nature. 1980 May 15;285(5761):159-60. doi: 10.1038/285159a0.
A diet which is marginally deficient in the vitamin biotin may cause sudden unexpected death of young broiler chickens when they are exposed to stress. Chickens affected with this disorder have low levels of biotin in their livers. In conditions of biotin insufficiency, we postulate that a similar disorder, triggered by mild stress, may occur in the human infant. We have now used a radiochemical technique to measure the biotin content of 204 livers obtained from infants at autopsy. The levels of biotin in the livers of infants who had died of sudden infant death syndrom (SIDS; cot death) were significantly lower than those in livers of infants of similar age, who had died of explicable causes. These findings support an association of biotin with SIDS.
一种生物素维生素略微缺乏的饮食，可能会导致幼龄肉鸡在遭受应激时突然意外死亡。患有这种疾病的鸡肝脏中的生物素水平较低。在生物素不足的情况下，我们推测，由轻度应激引发的类似疾病可能会在人类婴儿中出现。我们现在使用一种放射化学技术来测量从尸检婴儿身上获取的204个肝脏的生物素含量。死于婴儿猝死综合征（SIDS；摇篮死亡）的婴儿肝脏中的生物素水平，明显低于死于可解释原因的同龄婴儿肝脏中的生物素水平。这些发现支持了生物素与婴儿猝死综合征之间的关联。
