Gabellec M M, Recasens M, Benezra R, Mandel P
Neurochem Res. 1980 Mar;5(3):309-17. doi: 10.1007/BF00964619.
The distributions of gamma-aminobutyric acid (GABA), glutamate decarboxylase (GAD), and gamma-aminobutyrate transaminase (GABA-T) have been studied in various brain areas of mice. These neurochemical markers, which are related to inhibitory neurotransmission, were investigated in different inbred strains of mice (C3H/He, C57/BR, and their F1 hybrids). The regional distributions of GABA, GAD activity, and GABA-T activity in adult mice of these three strains were quite similar. No significant differences were found in any brain area for GAD or GABA-T activity. However, significant differences in GABA level were found in several brain areas among these strains of mice, especially in hypothalamus, hippocampus, olfactory bulb, and occipital cortex. These results provide further information to the possible influence of the GABAergic system in these brain areas.
已经在小鼠的各个脑区研究了γ-氨基丁酸（GABA）、谷氨酸脱羧酶（GAD）和γ-氨基丁酸转氨酶（GABA-T）的分布。这些与抑制性神经传递相关的神经化学标志物，在不同的近交系小鼠（C3H/He、C57/BR及其F1杂种）中进行了研究。这三个品系成年小鼠中GABA、GAD活性和GABA-T活性的区域分布非常相似。在任何脑区，GAD或GABA-T活性均未发现显著差异。然而，在这些品系的小鼠中，几个脑区的GABA水平存在显著差异，尤其是在下丘脑、海马体、嗅球和枕叶皮质。这些结果为GABA能系统在这些脑区可能产生的影响提供了进一步的信息。
