Kelly J, Alheid G F, Newberg A, Grossman S P
Pharmacol Biochem Behav. 1977 Dec;7(6):537-41. doi: 10.1016/0091-3057(77)90250-7.
Microinjections of the gamma-aminobutyric acid (GABA) antagonist, bicuculline methiodide (BM) (100 ng), into the anterolateral hypothalamus (LH) increased ingestion of sweet milk. A subsequent injection of BM 48 hrs. later produced a type of kindling effect consisting of feeding related automatisms, such as gnawing and biting. The behavioral effects of injections of 100 ng of GABA into the LH were variable. GABA injections into the ventromedial hypothalamus (VMH) reliably increased food intake. GABA injections into the origin of the nigrostriatal dopamine (DA) neurons in the substantia nigra (SN) suppressed it. Similar injections into the origin of the mesolimbic DA cells in the ventral tegmental area (VTA) had no effect on feeding behavior. Following BM injections into the SN, a moderate increase in tilt box activity was observed. A second injection of the GABA blocker 6 days later exaggerated this effect. Short latency extreme hyperactivation was accompanied by unidirectional barrel rolling which persisted until blocked by local injections of GABA.
向外侧下丘脑（LH）微量注射γ-氨基丁酸（GABA）拮抗剂甲磺酸荷包牡丹碱（BM）（100纳克）会增加甜牛奶的摄入量。48小时后再次注射BM会产生一种点燃效应，表现为与进食相关的自动行为，如啃咬和撕咬。向LH注射100纳克GABA的行为效应各不相同。向腹内侧下丘脑（VMH）注射GABA确实会增加食物摄入量。向黑质（SN）中黑质纹状体多巴胺（DA）神经元的起源部位注射GABA会抑制食物摄入。向腹侧被盖区（VTA）中中脑边缘DA细胞的起源部位进行类似注射对进食行为没有影响。向SN注射BM后，观察到倾斜箱活动有适度增加。6天后再次注射GABA阻断剂会使这种效应增强。短潜伏期的极度过度激活伴随着单向翻滚，这种翻滚会持续存在，直到通过局部注射GABA使其停止。
