Manzoni G C, Terzano M G, Parma M
Minerva Med. 1980 Apr 2;71(13):947-52.
Therapeutic effectiveness of lithium carbonate in cluster headache is confirmed on the ground of the results in 20 patients (14 with the episodic form, 6 with the chronic one). Outstanding findings were: a) the early effectiveness; b) the occurrence of therapeutic effects even with low doses; c) the negligible risk of side effects. The way interrupting the treatment in episodic cluster headache is proposed. In chronic cluster headache recurrence can be expected when lithium is stopped, but in some cases it occurs after a long free interval. The contrast is stressed between the high efficacy in all the 20 patients with cluster headache and the complete uneffectiveness in 5 patients affected by headaches considered as borderline between cluster headache and migraine.
基于20例患者(14例发作性,6例慢性)的结果,碳酸锂对丛集性头痛的治疗效果得到证实。突出的发现有:a)起效早;b)即使低剂量也有治疗效果;c)副作用风险可忽略不计。提出了发作性丛集性头痛中断治疗的方法。在慢性丛集性头痛中,停用锂时可能会复发,但在某些情况下,复发会在长时间的无发作间隔后出现。强调了20例丛集性头痛患者全部疗效显著与5例被认为处于丛集性头痛和偏头痛边界的头痛患者完全无效之间的对比。