Stevenson D K, Bartoletti A L, Ostrander C R, Johnson J D
Pediatrics. 1980 Jun;65(6):1170-2.
Measurements of the pulmonary excretion rate of carbon monoxide (VEco) as an index of bilirubin production in the first several days of life were taken from 64 breast-fed or bottle-fed infants. Twenty-one infants (greater than or equal to 37 weeks of gestation) were breast-fed; 43 infants (28 to 42 weeks of gestation) were bottle-fed a commercially prepared formula. Information pertaining to their caloric intake during the 24-hour period preceding VEco determination was taken from 38 of the 43 infants who were bottle-fed and they were placed into three groups based on their caloric intake: (1) less than or equal to 60 kcal/kg/day (19 infants); (2) 61 to 100 kcal/kg/day (7 infants); and (3) greater than 100 kcal/kg/day (12 infants). There was no significant difference in bilirubin production between bottle-fed and breast-fed infants. No effect of caloric deprivation on bilirubin production was demonstrated. The mean VEco values were 18.5 +/- 0.9 (SE) for group 1, 17.7 +/- 1.8 (SE) for group 2, and 16.2 +/- 1.1 (SE) microliter/kg/hr for group 3.
对64名母乳喂养或人工喂养婴儿在出生后最初几天的一氧化碳肺排泄率（VEco）进行了测量，以此作为胆红素生成的指标。21名（胎龄大于或等于37周）婴儿为母乳喂养；43名（胎龄28至42周）婴儿人工喂养市售配方奶粉。对43名人工喂养婴儿中的38名，采集了其在测定VEco前24小时内的热量摄入信息，并根据热量摄入将他们分为三组：（1）小于或等于60千卡/千克/天（19名婴儿）；（2）61至100千卡/千克/天（7名婴儿）；（3）大于100千卡/千克/天（12名婴儿）。人工喂养婴儿和母乳喂养婴儿的胆红素生成无显著差异。未显示热量剥夺对胆红素生成有影响。第1组的平均VEco值为18.5±0.9（标准误），第2组为17.7±1.8（标准误），第3组为16.2±1.1（标准误）微升/千克/小时。
