小鼠和豚鼠体内3H-地高辛组织分布及摄取的年龄相关变化
Age-associated changes in tissue distribution and uptake of 3H-digoxin in mice and guinea pigs.
作者信息
Kroening B H, Weintraub M
出版信息
Pharmacology. 1980;20(1):21-6. doi: 10.1159/000137339.
The influence of age on tissue distribution of digoxin in mice and guinea pigs and uptake by mouse heart slices was investigated. 4 h after a single dose of 3 H-digoxin, tissue:plasma ratios were significantly greater in very young animals and declined with increasing age. A similar relationship was apparent for packed red blood cell:plasma concentration ratios in mice. Uptake of 3H-digoxin by heart tissue slices was also higher for 21-day-old mice than 200-day-old mice. These data seem to correlate with the larger volume of distribution of digoxin observed in the young. Tissue digoxin relative to plasma concentration seems higher in the young, although they appear less sensitive to the effects of cardiac glycosides.
研究了年龄对小鼠和豚鼠体内地高辛组织分布以及小鼠心脏切片摄取地高辛的影响。单次给予3H-地高辛4小时后，非常年幼的动物组织与血浆的比值显著更高，且随年龄增长而下降。小鼠中红细胞压积与血浆浓度的比值也呈现类似关系。21日龄小鼠心脏组织切片对3H-地高辛的摄取也高于200日龄小鼠。这些数据似乎与在年幼动物中观察到的地高辛更大分布容积相关。尽管年幼动物对地高辛的作用似乎不太敏感，但相对于血浆浓度而言，组织中的地高辛含量在年幼动物中似乎更高。
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