Russell P H
Res Vet Sci. 1980 Jan;28(1):39-43.
Rabbits with malignant catarrhal fever were recently found to have depressed T and B cell function which was shown by failure of their blood lymphocytes to respond to phytohaemagglutinin (PHA) and other mitogens. In the present work, in contrast, lymphocytes from diseased calves were found to respond well to PHA. Despite using the same source of rabbits and virus as in the earlier study the PHA response of lymph node or peripheral blood cells of rabbits was also found to be normal in most instances but depressed in others; conclusive evidence for hyporesponsiveness due to serum mediated suppression was absent.
最近发现患有恶性卡他热的兔子T细胞和B细胞功能受到抑制，这表现为其血液淋巴细胞对植物血凝素（PHA）和其他有丝分裂原无反应。相比之下，在本研究中，发现患病小牛的淋巴细胞对PHA反应良好。尽管使用了与早期研究相同的兔子来源和病毒，但在大多数情况下，兔子淋巴结或外周血细胞对PHA的反应也正常，但在其他情况下则受到抑制；缺乏血清介导抑制导致反应性降低的确凿证据。
