Rossiter P B, Mushi E Z, Plowright W
Res Vet Sci. 1978 Sep;25(2):207-10.
Cytosine arabinoside (Ara-C) inhibited the production of late antigens and of infectious virus in monolayers of bovine kidney cells infected with the high-passage, WC-11 strain of malignant catarrhal fever virus. Early antigens were not affected. Using hyperimmune and acute-phase sera from cattle and rabbits in indirect immunofluorescence tests, it was shown that Ara-C treated cultures contained two early antigens; one was diffuse and distributed throughout the cells, the other was particulate and intranuclear. Antibody to early antigens developed later and attained lower titres in infected animals, especially rabbits; only hyperimmune sera reacted with the diffuse early antigen.
阿糖胞苷（Ara-C）抑制了感染高代恶性卡他热病毒WC-11株的牛肾单层细胞中晚期抗原和传染性病毒的产生。早期抗原未受影响。在间接免疫荧光试验中，使用来自牛和兔的超免疫血清和急性期血清，结果显示经阿糖胞苷处理的培养物含有两种早期抗原；一种呈弥漫性，分布于整个细胞，另一种呈颗粒状，位于细胞核内。早期抗原抗体在感染动物中出现较晚，且效价较低，尤其是在兔中；只有超免疫血清能与弥漫性早期抗原发生反应。
