Meberg A
Scand J Haematol. 1980 Feb;24(2):162-8. doi: 10.1111/j.1600-0609.1980.tb02362.x.
Capillary Hb concentration on the first day of life was registered in 201 infants with weight appropriate for gestational age (AGA) and in 99 infants small for gestational age (SGA). In both groups Hb increased towards term (P less than 0.01), while the SGA infants reached higher Hb concentration at term (21.5 +/- 1.9 g/dl; mean +/- SD) than the AGA infants (17.9 +/- 1.5 g/dl) (P less than 0.001). The cord serum erythropoietin (EP) level increased towards term equally in both groups. Delivery did not seem to influence the EP level as same values were obtained in cord serum from infants delivered by elective cesarean section as after uncomplicated vaginal delivery. No correlation was found between cord serum EP and first day capillary PCV. Postnatally a rapid fall in the EP level occurred. In healthy adults no serum EP activity was detected. It is suggested that increasing hypoxia, rapid growth, and shift from hepatic to myeloid erythropoiesis may be related to the increasing Hb concentration and serum EP level towards term. Improvement of oxygenation during air breathing may cause the decreasing serum EP level after birth.
对201名适于胎龄（AGA）婴儿和99名小于胎龄（SGA）婴儿出生第一天的毛细血管血红蛋白浓度进行了记录。两组婴儿的血红蛋白水平均随孕周增加而升高（P<0.01），而足月时SGA婴儿的血红蛋白浓度（21.5±1.9g/dl；均值±标准差）高于AGA婴儿（17.9±1.5g/dl）（P<0.001）。两组婴儿脐带血清促红细胞生成素（EP）水平均随孕周增加。分娩方式似乎不影响EP水平，择期剖宫产分娩婴儿的脐带血清EP水平与无并发症阴道分娩后的水平相同。脐带血清EP与出生第一天毛细血管血细胞比容之间未发现相关性。出生后EP水平迅速下降。健康成年人未检测到血清EP活性。提示缺氧增加、快速生长以及从肝脏造血向骨髓造血的转变可能与孕周增加时血红蛋白浓度和血清EP水平升高有关。出生后呼吸空气时氧合改善可能导致血清EP水平下降。
