Törngren S, Hägglund G, Molin K, Rieger A
Scand J Infect Dis. 1980;12(2):123-7. doi: 10.3109/inf.1980.12.issue-2.09.
The connection between deep venous thrombosis (DVT) and postoperative infectious complications (PIC) was studied in 170 patients (mean age 65.7 and 40--86 years) who had undergone open large bowel or rectal surgery. DVT was diagnosed by the 125I-fibrinogen method. DVT of the legs was found in 36 patients. In 58 patients with PIC the frequency of DVT in 41 patients receiving low-dose heparin was 29% and in 17 patients without heparin prophylaxis 71% (P less than 0.01). In 112 patients without infection the frequency of DVT in 98 patients receiving low-dose heparin was 12% and 14 patients without heparin prophylaxis 7%. The frequency of DVT was significantly lower in patients without infection compared to those with PIC (P less than 0.001). Serious DVTs were more common in patients with PIC compared to those without PIC (P less than 0.05). It is concluded that infections after open large bowel and rectal surgery is an important risk factor for the development of DVT. Low-dose heparin significantly reduces the frequency of DVT in infected patients.
对170例接受开放性大肠或直肠手术的患者（平均年龄65.7岁，年龄范围40 - 86岁）进行了深静脉血栓形成（DVT）与术后感染并发症（PIC）之间关系的研究。采用¹²⁵I - 纤维蛋白原法诊断DVT。发现36例患者存在下肢DVT。在58例有PIC的患者中，41例接受低剂量肝素治疗的患者DVT发生率为29%，17例未接受肝素预防的患者DVT发生率为71%（P < 0.01）。在112例无感染的患者中，98例接受低剂量肝素治疗的患者DVT发生率为12%，14例未接受肝素预防的患者DVT发生率为7%。与有PIC的患者相比，无感染患者的DVT发生率显著更低（P < 0.001）。与无PIC的患者相比，严重DVT在有PIC的患者中更常见（P < 0.05）。结论是开放性大肠和直肠手术后的感染是DVT发生的重要危险因素。低剂量肝素可显著降低感染患者的DVT发生率。
