精神分裂症患者血浆中单胺氧化酶内源性抑制剂的进一步研究。

Further studies on the endogenous inhibitor of monoamine oxidase in schizophrenic plasma.

作者信息

Vogel W H, Ladman R K, Berrettini W H

出版信息

Schizophr Bull. 1980;6(2):232-4. doi: 10.1093/schbul/6.2.232.

DOI:10.1093/schbul/6.2.232

Abstract

Platelet-free plasma from schizophrenic patients satisfying research diagnostic criteria for chronic schizophrenia was obtained and mixed with platelet-rich plasma from normal controls. Decreases in control platelet monoamine oxidase activity were observed, with some control platelets apparently much more sensitive than others to the inhibitory activity of the chronic schizophrenic plasma. Experimental conditions and selection from sensitive control individuals seem crucial in demonstrating the presence of endogenous inhibitors in schizophrenics' plasma.

摘要

获取符合慢性精神分裂症研究诊断标准的精神分裂症患者的无血小板血浆，并将其与正常对照者的富含血小板血浆混合。观察到对照血小板单胺氧化酶活性降低，一些对照血小板对慢性精神分裂症血浆的抑制活性明显比其他血小板更敏感。实验条件以及从敏感对照个体中进行选择，对于证明精神分裂症患者血浆中存在内源性抑制剂似乎至关重要。